Setting up a new BizTalk Server environment on the Azure IaaS with multiple Azure Virtual Machines (VM) involves a lot of steps and prerequisites. I have explained them in this blog.
Firstly, sign up for a new Azure subscription or add your Live ID as the co-admin in the Azure subscription if one already exists.
After the co-admin/sys admin privileges, you can choose to administer the Azure subscriptions in these ways: a) Azure PowerShell cmdlets b) Azure Management Portal.
I have used the Azure management portal for provisioning all cloud entities as it is more convenient and a time saver. Below is the architecture diagram that explains the BizTalk environment in Azure IaaS.